titeIR: Isotonic Designs for Phase 1 Trials with Late-Onset Toxicities

Functions to design phase 1 trials using an isotonic regression based design incorporating time-to-event information. Simulation and design functions are available, which incorporate information about followup and DLTs, and apply isotonic regression to devise estimates of DLT probability.

Version: 0.1.0
Imports: Iso
Published: 2018-09-28
DOI: 10.32614/CRAN.package.titeIR
Author: Lee McDaniel [aut, cre]
Maintainer: Lee McDaniel <lmcda4 at lsuhsc.edu>
License: GPL-3
NeedsCompilation: no
CRAN checks: titeIR results


Reference manual: titeIR.pdf


Package source: titeIR_0.1.0.tar.gz
Windows binaries: r-devel: titeIR_0.1.0.zip, r-release: titeIR_0.1.0.zip, r-oldrel: titeIR_0.1.0.zip
macOS binaries: r-release (arm64): titeIR_0.1.0.tgz, r-oldrel (arm64): titeIR_0.1.0.tgz, r-release (x86_64): titeIR_0.1.0.tgz, r-oldrel (x86_64): titeIR_0.1.0.tgz


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