HybridDesign: Hybrid Design for Phase I Dose-Finding Studies

The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.

Version: 1.0
Depends: R (≥ 3.6)
Imports: testit, ResourceSelection
Published: 2022-12-15
DOI: 10.32614/CRAN.package.HybridDesign
Author: Heng Zhou [aut, cre], Feng Zhou [aut], Jason Liao [aut]
Maintainer: Heng Zhou <heng.zhou at merck.com>
License: GPL-3
NeedsCompilation: no
CRAN checks: HybridDesign results


Reference manual: HybridDesign.pdf


Package source: HybridDesign_1.0.tar.gz
Windows binaries: r-devel: HybridDesign_1.0.zip, r-release: HybridDesign_1.0.zip, r-oldrel: HybridDesign_1.0.zip
macOS binaries: r-release (arm64): HybridDesign_1.0.tgz, r-oldrel (arm64): HybridDesign_1.0.tgz, r-release (x86_64): HybridDesign_1.0.tgz, r-oldrel (x86_64): HybridDesign_1.0.tgz


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