DrugSim2DR: Predict Drug Functional Similarity to Drug Repurposing

A systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. 'DrugSim2DR' first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.

Version: 0.1.1
Depends: R (≥ 3.6)
Imports: igraph, stats, pheatmap, ChemmineR, rvest, base, sp, tidyr, reshape2, fastmatch
Suggests: knitr, rmarkdown
Published: 2023-08-10
DOI: 10.32614/CRAN.package.DrugSim2DR
Author: Junwei Han [aut, cre, cph], Ji Li [aut], Jiashuo Wu [aut]
Maintainer: Junwei Han <hanjunwei1981 at 163.com>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: DrugSim2DR results


Reference manual: DrugSim2DR.pdf
Vignettes: DrugSim2DR User Guide


Package source: DrugSim2DR_0.1.1.tar.gz
Windows binaries: r-devel: DrugSim2DR_0.1.1.zip, r-release: DrugSim2DR_0.1.1.zip, r-oldrel: DrugSim2DR_0.1.1.zip
macOS binaries: r-release (arm64): DrugSim2DR_0.1.1.tgz, r-oldrel (arm64): DrugSim2DR_0.1.1.tgz, r-release (x86_64): DrugSim2DR_0.1.1.tgz, r-oldrel (x86_64): DrugSim2DR_0.1.1.tgz
Old sources: DrugSim2DR archive


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