For retrieving the PIN file for an organism of your choice, you may use the function
get_pin_file(). As of this version, the only source for PIN data is “BioGRID”.
By default, the function downloads the PIN data from BioGRID and processes it, saves it in a temporary file and returns the path:
You can retrieve the PIN data for the organism of your choice, by setting the
You may also supply a
path/to/PIN/file to save the PIN file for later use (in this case, the path you supply will be returned):
You may also retrieve a specific version of BioGRID via setting the
To retrieve organism-specific gene sets list, you may use the function
get_gene_sets_list(). The available sources for gene sets are “KEGG”, “Reactome” and “MSigDB”. The function retrieves the gene sets data from the source and processes it into a list of two objects used by pathfindR for active-subnetwork-oriented enrichment analysis: 1. gene_sets A list containing the genes involved in each gene set 2. descriptions A named vector containing the descriptions for each gene set
get_gene_sets_list() obtains “KEGG” gene sets for “hsa”.
To obtain the gene sets list of the KEGG pathways for an organism of your choice, use the KEGG organism code for the selected organism. For a full list of all available organisms, see here.
For obtaining Reactome pathway gene sets, set the
source argument to “Reactome”. This downloads the most current Reactome pathways in gmt format and processes it into the list object that pathfindR uses:
For Reactome, there is only one collection of pathway gene sets.
pathfindR can retrieve all MSigDB gene sets. For this, set the
source argument to “MSigDB” and the
collection argument to the desired MSigDB collection (one of H, C1, C2, C3, C4, C5, C6, C7):
The default organism for MSigDB is “Homo sapiens”, you may obtain the gene sets data for another organism by setting the
## see msigdbr::msigdbr_show_species() for all available organisms msigdbr::msigdbr_show_species() #>  "Bos taurus" "Caenorhabditis elegans" #>  "Canis lupus familiaris" "Danio rerio" #>  "Drosophila melanogaster" "Gallus gallus" #>  "Homo sapiens" "Mus musculus" #>  "Rattus norvegicus" "Saccharomyces cerevisiae" #>  "Sus scrofa"
You may also obtain the gene sets for a subcollection by setting the