metaRMST: Meta-Analysis of RMSTD

R implementation of a multivariate meta-analysis of randomized controlled trials (RCT) with the difference in restricted mean survival times (RMSTD). Use this package with individual patient level data from an RCT for a time-to-event outcome to determine combined effect estimates according to 4 methods: 1) a univariate meta-analysis using observed treatment effects, 2) a univariate meta-analysis using effects predicted by fitted Royston-Parmar flexible parametric models, 3) multivariate meta-analysis with analytically derived covariance, 4) multivariate meta-analysis with bootstrap derived covariance. This package computes all combined effects and provides an RMSTD curve with combined effect estimates and their confidence intervals.

Version: 1.0.0
Depends: R (≥ 3.4.0), rstpm2
Imports: mvmeta, meta, survival, survRM2, graphics
Published: 2018-12-18
Author: Isabelle Weir [aut, cre], Lu Tian [aut], Ludovic Trinquart [aut]
Maintainer: Isabelle Weir <iweir at>
License: GPL-2
NeedsCompilation: no
Materials: README
In views: MetaAnalysis
CRAN checks: metaRMST results


Reference manual: metaRMST.pdf


Package source: metaRMST_1.0.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): metaRMST_1.0.0.tgz, r-oldrel (arm64): metaRMST_1.0.0.tgz, r-release (x86_64): metaRMST_1.0.0.tgz, r-oldrel (x86_64): metaRMST_1.0.0.tgz


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