MLML2R: Maximum Likelihood Estimation of DNA Methylation and Hydroxymethylation Proportions

Maximum likelihood estimates (MLE) of the proportions of 5-mC and 5-hmC in the DNA using information from BS-conversion, TAB-conversion, and oxBS-conversion methods. One can use information from all three methods or any combination of two of them. Estimates are based on Binomial model by Qu et al. (2013) <doi:10.1093/bioinformatics/btt459> and Kiihl et al. (2019) <doi:10.1515/sagmb-2018-0031>.

Version: 0.3.3
Suggests: minfi, microbenchmark, GEOquery, knitr, rmarkdown, IlluminaHumanMethylation450kmanifest
Published: 2019-10-17
DOI: 10.32614/CRAN.package.MLML2R
Author: Samara Kiihl [aut, cre], Maria Jose Martinez-Garrido [aut], Arce Domingo-Relloso [aut], Jose Bermudez [aut], Maria Tellez-Plaza [aut]
Maintainer: Samara Kiihl <samara at>
License: MIT + file LICENSE
NeedsCompilation: no
Citation: MLML2R citation info
CRAN checks: MLML2R results


Reference manual: MLML2R.pdf
Vignettes: Using MLML2R


Package source: MLML2R_0.3.3.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): MLML2R_0.3.3.tgz, r-oldrel (arm64): MLML2R_0.3.3.tgz, r-release (x86_64): MLML2R_0.3.3.tgz, r-oldrel (x86_64): MLML2R_0.3.3.tgz
Old sources: MLML2R archive


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